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Chelerythrine Chloride
Naturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
产品信息
Form Light yellow to yellow solid
Primary Target PKC
Primary Target IC50 660 nM
Molar mass 383.8
Cell permeable 是的
Purity ≥97% by NMR
Solubility DMSO or H2O
Chemical formula C21H18NO4Cl
RTECS FL9200000
CAS number 3895-92-9
Merck USA index 14, 2051
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Harmful
安全标示
S Phrase S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
R Phrase R: 20/21/22-36/37/38
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin. |