|
Casein Kinase II Inhibitor I
TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
A cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively) and DYRK (IC50 < 1 µM for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC50 = 20 and 60 µM, using DNA and RNA substrate, respectively) and WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218708) in DMSO, is also available.
产品信息
Form White solid
Primary Target CK2 rat liver, human recombinant
Primary Target IC50 900 nM , 1.6 µM
Secondary target DYRK (IC50 > 1 µM for DYRK1a), WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively)
Molar mass 434.7
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
ATP Competitive 是的
Purity ≥99% by HPLC
Solubility DMSO
Chemical formula C6HBr4N3
CAS number 17374-26-4
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic |