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Casein Kinase I Inhibitor, D4476
CK1 Inhibitor, 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
A cell-permeable triaryl substituted imidazolo compound that acts as a potent, reversible and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 0.2 µM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 0.5 µM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and only weakly affects the activities of a panel of kinases tested, including PKB, SGK and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1a in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
产品信息
Form Crystalline solid
Primary Target CK1, CK1d
Primary Target IC50 0.2 µM, 0.3 µM
Secondary target ALK5 (IC50 = 0.5 µM), p38a MAP kinase (IC50 = 12 µM)
Molar mass 398.4
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
ATP Competitive 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C23H18N4O3
CAS number 301836-43-1
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |