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CDC25 Phosphatase Inhibitor II, NSC 663284
6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione, DA3003-1, PTP Inhibitor XXI, VHR Inhibitor II
A cell-permeable 7-substituted quinolinedione compound that displays antiproliferative properties. Acts as a potent, irreversible and mixed competitive inhibitor of the CDC25 phosphatase family (Ki = 29 nM, 95 nM and 89 nM for CDC25A, CDC25B2 and CDC25C, respectively; IC50 = 210 nM for CDC25B2) and displays nearly 20- and 450-fold greater selectivity for the CDC252 phosphatases over VHR and PTP1B (IC50 = 4.0 µM and > 100 µM, respectively). Reported to arrest cell cycle progression, inhibit Cdk dephosphorylation and delay tumor growth (IC50 = ~1.5 µM in NCI-60 tumor cell panel). Shown to modify CDC25A catalytic domain and to block cellular ERK dephosphorylation in HeLa-CDC25A cells.
产品信息
Form Red solid
Primary Target CD25A
Primary Target Ki 29 nM
Secondary target (Ki = 95 nM and 89 nM for CDC25B2 and CDC25C, respectively; IC50 = 210 nM for CDC25B2)
Molar mass 321.8
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C15H16ClN3O3
CAS number 383907-43-5
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic |