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CDC25 Phosphatase Inhibitor I, BN82002
N-(2-Hydroxy-3-methoxy-5-dimethylamino)benzyl, N′-(2-(4-nitrophenethyl)), N′′-methylamine, PTP Inhibitor XX
A cell-permeable ortho-hydroxybenzylamino compound that displays antitumor properties. Acts as a potent, selective and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 µM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Displays ~20-fold greater selectivity for CDC25 phosphatases over CD45 tyrosine phosphatase. Shown to delay cell cycle progression in vitro (IC50 = ~7.2-32.6 µM), and reduces tumor growth in athymic mice xenografted with the human pancreatic cells MIA PaCa-2 (15 mg/kg, i.p. route).
产品信息
Form Brown solid
Primary Target CDC25A
Primary Target IC50 2.1 µM
Secondary target IC50 = 3.9, 6.3, 5.4, and 4.6 µM for 25B2, 25B3, 25C, and 25C-cat, respectively
Molar mass 359.4
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility DMSO or EtOH
Chemical formula C19H25N3O4
CAS number 396073-89-5
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |