Bcl-xL BH44-23, Human, Cell-Permeable HIV-TAT48-57-β-Ala-Bcl-xL BH44-23, Ac-GRKKRRQRRR-βA-SNRELVVDFLSYKLSQKGYS-OH A cell-permeable peptide that prevents apoptotic cell death by directly binding to the voltage-dependent anion channel (VDAC) and blocking its activity. Leads to the inhibition of cytochrome c release and loss of mitochondrial membrane potential (ΔΨm). Contains the conserved N-terminal homology domain (BH4) of Bcl-xL (amino acids 4 - 23) that has been shown to be essential for inhibiting VDAC activity in liposomes and in isolated mitochondria. The BH4 domain is linked to a carrier peptide, a 10-amino acid HIV-TAT48-57 sequence with a β-alanine residue as a spacer for maximum flexibility. Following its uptake, it is mainly localized to the mitochondria. 产品信息 Peptide Sequence Ac-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-βAla-Ser-Asn-Arg-Glu-Leu-Val-Val-Asp-Phe-Leu-Ser-Tyr-Lys-Ser-Gln-Lys-Gly-Tyr-Ser-OH Form Lyophilized Formulation Supplied as a trifluoroacetate salt. Molar mass 3825.4 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥95% by HPLC Solubility DMSO Chemical formula C165H279N59O46 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling