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AKTINHIBITORXIII,ISOZYME-SELECTIVE,AKTI2

产品编号: 124030-2MG     查看说明书
产品名称: AKTINHIBITORXIII,ISOZYME-SELECTIVE,AKTI2  .0   订购此产品 
供应商: Merck
规格: ***
目录价: 3,065.00
库存状态: 3周到货
CAS编号:
应用范围: 生化实验
种属来源:
相关信息:

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2
N-(2-(Diethylamino)ethyl)-3-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinolinecarboxamide, 3HCl, N-(2-(Diethylamino)ethyl)-2-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinolinecarboxamide, 3HCl and
A highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC50 = 560 nM, 390 nM and 7.8 µM in in vitro kinase assay; 526 nM, 730 nM and > 10 µM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC50 > 50 µM). One of its potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells.
产品信息
Form  Yellow solid
Molar mass  763.2
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC (mixture of regioisomers)
Solubility  DMSO or H2O
Chemical formula  C40H43N7O2 • 3HCl
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling

保存条件: 2°C - 8°C
说明书地址: 点击查看详细
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