AKTINHIBITORXII,ISOZYME-SELECTIVE,AKTI-2

Akt Inhibitor XII, Isozyme-Selective, Akti-2
1-((3-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl, 1-((2-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl and
A cell-permeable Akti-1/2- (Cat. No. 124018) derived allosteric inhibitor pair (1:1 regioisomeric mixture) with much improved aqueous solubility (10 mg/ml in a pH 7.4 saline) and Akt2 selectivity (IC50 = 805 nM for Akt2, >10 µM for Akt1/3, and >50 µM for PKA/PKC/SGK). The inhibition is PH domain-dependent and non-competitive with ATP.
产品信息
Form  Yellow solid
Molar mass  747.2
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC (mixture of regioisomers)
Solubility  DMSO or H2O
Chemical formula  C39H39N7O2 • 3HCl
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling