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Akt Inhibitor X
10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP
A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039).
产品信息
Form White solid
Primary Target Akt
Primary Target IC50 <5 µM
Secondary target Rn cell lines (IC50 = 2-5 µM)
Molar mass 381.4
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility H2O
Chemical formula C20H25ClN2O • HCl
CAS number 925681-41-0
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant |