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Akt Inhibitor IX, API-59CJ-OMe
MMEA, 9-Methoxy-2-methylellipticinium acetate, NSC 627505
A cell-permeable ellipticine compound that potently and selectively induces apoptosis in human endometrial cancer cells (RL95-2 and Ishikawa) that exhibit elevated Akt activity (effective concentration = 12-24 µM), but not on cells with low Akt activity. Directly affects the activity by Akt, but not the level of cellular phosphorylation of Akt, ERK1/2, JNK1/2, PDK1, PKC isoforms, or serum and glucocorticoid-inducible kinase (SGK).
产品信息
Form Orange red solid
Primary Target Akt
Primary Target IC50 12-24 µM
Molar mass 404.5
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility H2O
Chemical formula C21H22N2O3 • 3H2O
CAS number 98510-80-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |