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Adenosine Kinase Inhibitor
4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, 2HCl, ABT-702
A cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors. It readily crosses the blood-brain barrier and is shown to be efficacious in in vivo animal models via various administration methods (i.p., p.o., s.c.).
产品信息
Form Yellow solid
Molar mass 536.3
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥90% by HPLC
Solubility DMSO
Chemical formula C22H19BrN6O •2HCl
CAS number 214697-26-4
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |