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Adenylyl Cyclase Type V Inhibitor, NKY80
2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
产品信息
Form Pale orange solid
Primary Target (AC) type V isoform
Primary Target IC50 8.3 µM
Secondary target (IC50 = 132 µM and 1.7 mM for type III and II, respectively) in the presence of Gsa GTPgS-Forskolin
Molar mass 229.2
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥97% by HPLC
Solubility DMSO or MeOH
Chemical formula C12H11N3O2
CAS number 299442-43-6
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Standard Handling |