正品|ACETYL-11-KETO-B-BOSWELLIC ACID

正品|ACETYL-11-KETO-B-BOSWELLIC ACID
产品信息 
Form  White solid 
Primary Target  5-lipoxygenase 
Primary Target IC50  1.5 µM in rat PMNLs 
Protect from Light  是的 
Packaged under inert gas  是的 
Cell permeable  是的 
Purity  ≥98% by HPLC 
Chemical formula  C32H48O5 
CAS number  67416-61-9 
Storage  +2°C to +8°C 
Ship  Ambient Temperature Only
Carcinogenic / Teratogenic 
产品说明
A cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥ 10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.