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Anti-phospho-PDGFRβ (Tyr716) Antibody
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REFERENCES
Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model.
Preeti J Khandelwal,Sonya B Dumanis,Li Rebekah Feng,Kathleen Maguire-Zeiss,Gw Rebeck,Hilal A Lashuel,Charbel Eh Moussa (2010) Molecular neurodegeneration.5
Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination.
Rafaela Holtappels,Christian O Simon,Michael W Munks,Doris Thomas,Petra Deegen,Birgit Kühnapfel,Torsten Däubner,Simone F Emde,Jürgen Podlech,Natascha K A Grzimek,Silke A Oehrlein-Karpi,Ann B Hill,Matthias J Reddehase (2008) Journal of virology.82
Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248.
Olga Potapova, A Douglas Laird, Michelle A Nannini, Angela Barone, Guangmin Li, Katherine G Moss, Julie M Cherrington, Dirk B Mendel (2006) Molecular cancer therapeutics.5:1280-9
Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events.
Baxter, R M, et al. (1998) J. Biol. Chem., 273: 17050-5 (1998)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rabbit Purified Polyclonal Antibody
Description:
Anti-phospho-PDGFRβ (Tyr716) Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes PDGF Receptor β phosphorylated at Tyr716.
Molecular Weight:
190 kDa
Immunogen:
peptide corresponding to amino acids 710-718 of human PDGF Receptor b (C-PPSAELpYSN)
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Control:
PDGF stimulated human HFF or mouse 3T3 cells
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from PDGF-stimulated human HFF cells or PDGF-stimulated mouse 3T3 cells
Purification Method:
Protein A purfied
Presentation:
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
P09619
Entrez Gene Number:
NM_002608
Gene Symbol:
PDGFRB
PDGF-R-beta
PDGFR
JTK12
CD140B
PDGFR1
CD140b
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation bet |