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Mycalolide B
Depolymerizes actin
Mycalolide B is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM). It selectively and completely depolymerizes F-actin to G-actin via a mechanism distinct from that of the cytochalasins. Unlike cytochalasins, it inhibits actin-activated Mg2+-ATPase from rabbit skeletal muscle.
Product Specification
Formula: C52H74N4O17
MW: 1027.2
Source: Isolated from the marine sponge Mycale sp.
CAS: 122752-21-0
Purity: ≥98% (HPLC)
Appearance: Clear to white solid
Hazard: TOXIC.
Solubility: Soluble in DMSO, methanol or isopropanol
Long Term Storage: -20°C
Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |