Latrunculin B Ultra-pure; inhibits actin polymerization Structurally unique marine toxin. Actin filament modulator. 10- to 100-fold more potent than cytochalasins. Whereas cytochalasin D (Prod. No. BML-T109) induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, latrunculin B causes a shortening and thickening of stress fibers. Effects on N1E-115 cells (mouse neuroblastoma) at concentrations as low as 90nM (NI43T3 cells, 0.9µM). Maximum effects at 2.5µM. Slowly inactivated by fetal bovine serum. Inhibition of cofilin-actin binding (ED50~50µM) Product Specification Formula: C20H29NO5S MW: 395.5 Source: Isolated from Latrunculia magnifica. CAS: 76343-94-7 MI: 14: 5378 Purity: ≥98% (HPLC) Appearance: Lyophilized solid Hazard: HARMFUL. Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). Long Term Storage: -20°C
