Cytochalasin D Ultra-pure; inhibits actin polymerization; K+ channel blocker Cytochalasin D is a cell-permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It is about 10-fold more effective than cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K+ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Induces apoptosis. Product Specification Formula: C30H37NO6 MW: 507.6 Source: Isolated from Zygosporium mansonii CAS: 22144-77-0 Purity: ≥98% (HPLC, TLC) Appearance: White to off-white solid Hazard: VERY TOXIC. Solubility: Soluble in methylene chloride (10mg/ml) or DMSO (up to 25mg/ml) Long Term Storage: -20°C Handling: Protect from light.
