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Heme oxygenase 1, pAb

产品编号: BML-HC3001-0025     查看说明书
产品名称: Heme oxygenase 1, pAb  .0   订购此产品 
供应商: Biomol
规格: 25 ul
目录价: 1467.75
库存状态: 3周到货
CAS编号:
应用范围: 生化实验
种属来源:
相关信息:

Product Specification
Alternative Name:HMOX1, Hsp32, Heat shock protein 32, HO-1
Host:Rabbit
Immunogen:Synthetic peptide corresponding to aa 12-25 of human heme oxygenase 1 (HO-1) protein.
UniProt ID:P09601
Application:Immunohistochemistry (1:50 – 1:1'000)
Western Blot (1:1'000)
Optimal conditions must be determined individually for each application.
Specificity:Recognizes human heme oxygenase 1.
Formulation:Liquid. Antiserum containing 10mM sodium azide.
Handling:Store unopened vial at -20°C until required for use. Store diluted antibody at 2-4°C and use within 1 month. Avoid freeze/thaw cycles.
Long Term Storage:-20°C
Miscellaneous/General:The rate limiting enzyme in heme catabolism, heme oxygenase, was first described in 1968 and was thought to be a species of cytochrome P450. However, subsequent work showed the enzyme to be a protein distinct from the P450 family and capable of catalysing the degradation of heme to biliverdin and iron, with the concomitant release of carbon monoxide. This enzyme activity is highly conserved throughout the Animal Kingdom and has been identified in algae and plants as well as in all higher species. Heme oxygenase-1 (HO-1) was first purified to homogeneity from rat liver and pig spleen and shown to have a molecular weight of 32kDa. Increased expression of HO-1 can be induced by a large number of structurally unrelated pharmacological and other agents, including cytokines and oxidants, as well as by heat shock and other forms of cellular stress. Baseline levels of HO-1 expression are high in certain tissues, including spleen and liver, but enriched enzyme preparations are recommended for experimental analysis. Recent data have demonstrated a cytoprotective role for HO-1, preventing cell death by modulating intracellular iron levels.

保存条件: -20°C
说明书地址: 点击查看详细
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