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FADD Antibody (Clone T1B)
Product Overview
Antibody Target: FADD
Alternative Name: FAS-associated death domain protein, GIG3, MGC8528, MORT1
Host: Mouse
Antibody Type: Monoclonal (Clone T1B)
Isotype: Mouse IgG1
Immunogen: Recombinant human FADD
Accession#: NM_003824
Gene ID: 8772
Appearance: Colorless liquid
Concentration: 0.2 mg/ml
Formulation: 100 µg (200 µg/ml) affinity purified antibody in PBS containing 30% glycerol, 0.5% BSA and 0.01% thimerosal
Purification: Affinity purified
Species Reactivity: human, mouse, dog
Application: Western blot, Immunofluorescence
Application & Usage: Western blot analysis (1-4 µg/ml). The antibody detects 28 kDa protein, corresponding to the apparent molecular weight of FADD in SDS-PAGE However, the optimal conditions should be determined individually. HeLa cell lysate can be used as a positive control.immunoblots from samples of human and mouse origins.
Storage Temp.: -20 °C
Shipping: gel pack
Background Descriptions: Fas-associating death domain containing protein (FADD), also known as mediator of receptor induced toxicity (MORT1), is a 24 kDa cytosolic protein. The protein is involved in both Fas and TNF-R induced cell death pathway. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that can be inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death.
Handling: The antibody solution should be gently mixed before use.
Usage: For Research Use Only! Not to be used in humans. |