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Splitomicin
Product Overview
Product Name: Splitomicin
Alternate Name/Synonyms: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Description: Potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC₅₀ = 60 µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1384339
Molecular Formula: C₁₃H₁₀O₂
Molecular Weight: 198.2
Purity: ≥98%
Solubility:DMSO (100 mg/ml)
Storage Temp.: +4°C
Shipping Conditions: RT
Handling: Protect from air and moisture
SMILES: C1CC(=O)OC2=C1C3=CC=CC=C3C=C2
InChi: InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
InChi Key: ISFPDBUKMJDAJH-UHFFFAOYSA-N
PubChem CID: 5269
MDL Number: MFCD08705254
USAGE: For Research Use Only! Not For Use in Humans. |