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DECTIN-1
Coding sequence in expression plasmid
Alias: CLEC7A, CLECSF12
Dectin-1
C-type lectin domain family 7, member A
C-type lectin-like receptor superfamily 12B
Dectin-1 is a C-type lectin expressed on phagocytic cells, including macrophages and neutrophils, that recognizes and responds to live fungal pathogens.
Dectin-1 mediates both the internalization and cellular responses to beta-glucan containing particles such as Zymosan, a cell wall preparation of Saccharomyces cerevisiae, through unique mechanisms [1]. Zymosan is also recognized by TLR2/TLR6 heterodimers which signaling mediates the activation of NF-kB and the production of inflammatory cytokines. Recent data suggest that Dectin-1 and TLR2/TLR6 signaling combine to enhance the responses triggered by each receptor [2,3].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin.
Bovine DECTIN1 isoform_1 (pUNO1-bDectin1a)
ORF Size: 744 bp
Subclone: AgeI - NheI
Bovine DECTIN1 isoform_2 (pUNO1-bDectin1b)
ORF Size: 606 bp
Subclone: AgeI - NheI
Human DECTIN1 isoform 1 (longest) (pUNO1-hDectin1a)
ORF Size: 744 bp
Subclone: AgeI - NheI
Human DECTIN1 isoform 2 (major variant B) (pUNO1-hDectin1b)
Genbank: NM_022570.4
ORF Size: 606 bp
Subclone: AgeI - NheI
Mouse DECTIN1 isoform_1 (pUNO1-mDectin1a)
ORF Size: 735 bp
Subclone: BspHI - NheI
Mouse DECTIN1 isoform_2 (pUNO1-mDectin1b)
ORF Size: 600 bp
Subclone: BspHI - NheI
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