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HKMT
Heat-killed Mycobacterium tuberculosis
HKMT is a heat-killed preparation of the avirulent strain of Mycobacterium tuberculosis H37 Ra.
HKMT is sensed by Mincle which recognizes the mycobacterial cell wall glycolipid TDM [1]. HKMT also possesses a large repertoire of TLR2 ligands, such as lipoproteins and lipomannan [2]. Upon HKMT sensing, both Mincle and TLR2 lead to the activation of NF-κB.
Specificity: Mincle agonist, TLR2 agonist
Working concentration:
• 10 - 100 µg/ml when used as a Mincle ligand
• 100 ng - 10 µg/ml when used as a TLR2 ligand |