|
CFA
Vaccine Adjuvant: Complete Freund’s Adjuvant
Complete Freund's Adjuvant (CFA) consists of heat-killed Mycobacterium tuberculosis in a water-in-oil emulsion. CFA contains trehalose 6,6’ dimycolate (TDM), which stimulates Mincle. Additionally, CFA has ligands for TLR2, TLR4, and TLR9.
Injection of antigen in CFA induces a Th1-dominated response when compared to injection in Incomplete Freund's Adjuvant (IFA), which lacks mycobacterial components and induces a Th2-dominated response.
An essential component of CFA-mediated response is an intense inflammatory reaction at the site of antigen deposition. For most applications, CFA is usually only necessary for the initial immunization, while IFA is the adjuvant of choice for subsequent immunizations.
CFA is for research use only, not for use in humans.
Specificity: Th1 response
VacciGrade™ (preclinical grade).
Endotoxin level: <1 EU/ml |