SIRT7 (2-400 aa) (His-tagged), Human recombinant

SIRT7 (2-400 aa) (His-tagged), Human recombinant
Intracellular regulatory proteins with mono-ADP-ribosyltransferaseﾠactivity.
Product Overview
Product Name: SIRT7 (2-400 aa) (His-tagged), Human recombinant
Alternate Name/Synonyms: NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7
Gene Symbol: SIRT7
Accession #: Q9NRC8
Gene ID: 7799
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 7.5, containing 150 mM sodium chloride and 20% glycerol.
Molecular Weight: 49.3 kDa (2-400 aa, NT His Tag)
Purity by SDS-PAGE: ≥85%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.