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Ash2L (96-628 aa), Human recombinant
A novel oncoprotein
Product Overview
Product Name: Ash2L (96-628 aa), Human recombinant
Alternate Name/Synonyms: Set1/Ash2 Histone Methyltransferase Complex Subunit Ash2 Isoform A; Absent, small, or homeotic discs 2-like
Gene Symbol: ASH2L
Accession #: Q9UBL3
Gene ID: 27443
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol.
Molecular Weight: 60.1 kDa (96-628 aa)
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: ASH2L is the human homolog of the Drosophila absent, small or homeotic discs 2 (ash2) gene product, a member of the trithorax group (TrxG) of proteins.The TrxG gene products in Drosophila and their mammalian homologs are responsible for controlling gene transcription. The ASH2L protein is a component of various multisubunit protein complexes, including the large complex of proteins associated with the SET1 (MLL) family of lysine methyltransferases. ASH2L, along with WDR5 and RbBP5, form the human MLL1 core protein complex. MLL1-5 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation. Post-translational modifications of ASH2L have also been described showing methylation of Arg-296 by protein-arginine methyltransferease 1 (PRMT1) in vitro and in cells and by PRMT5 in vitro. Further experimental evidence in rats suggests that ASH2L cooperates with Ha-RAS to transform rat embryonic fibroblasts, implicating ASH2L as a novel oncoprotein.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |