CECR2 bromodomain (424-538 aa) (GST-tagged), Human recombinant

CECR2 bromodomain (424-538 aa) (GST-tagged), Human recombinant
Plays a role in DNA danage response and neurulation
Product Overview
Product Name: CECR2 bromodomain (424-538 aa) (GST-tagged), Human recombinant
Alternate Name/Synonyms: Cat Eye Syndrome Critical Region Protein 2
Gene Symbol: CECR2
Accession #: Q9BXF3
Gene ID: 27443
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol.
Molecular Weight: 40.6 kDa (424-538 aa + NT GST Tag)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. Cat eye syndrome critical region protein 2 (CECR2) is a transcription factor that forms a heterodimeric complex with the ATP-dependent chromatin remodeler SNF2L forming the CECR2-containing-remodeling factor (CERF). The CERF complex plays a critical role in neurulation. More recently, the bromodomain of CECR2 was shown to have strong γ-H2AX inhibition activity suggesting that CECR2 may play a role in DNA damage response.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.