TAF1 bromodomain 1 (1371-1496 aa) (GST-tagged), Human recombinant

TAF1 bromodomain 1 (1371-1496 aa) (GST-tagged), Human recombinant
A component of transcription factor IID
Product Overview
Product Name: TAF1 bromodomain 1 (1371-1496 aa) (GST-tagged), Human recombinant
Alternate Name/Synonyms: TATA Box Binding Protein (TBP)-Associated Factor; KAT4; DYT3; CCGS; NSCL2; XDP; TAF1 RNA Polymerase II; TAF2A; TAFII250; BA2R; CCG1
Gene Symbol: TAF1
Accession #: P21675
Gene ID: 6872
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
Molecular Weight: 41.7 kDa (1371-1496 aa + NT GST Tag)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.