CREB Binding Protein bromodomain (1081-1197 aa) (GST-tagged), Human recombinant

CREB Binding Protein bromodomain (1081-1197 aa) (GST-tagged), Human recombinant
A bromodomain modulating the stability and function of tumor suppressor protein p53
Product Overview
Product Name: CREB Binding Protein bromodomain (1081-1197 aa) (GST-tagged), Human recombinant
Alternate Name/Synonyms: cAMP-responsive element-binding protein 1 CREB-1; CBP; CREBBP
Gene Symbol: CREB1
Accession #: P16220
Gene ID: 1385
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
Molecular Weight: 40.8 kDa (1081-1197 aa + NT GST Tag)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The cAMP response element-binding protein (CREB) binding protein (CREBBP) bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53. This product contains the bromodomain region of CREBBP.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.