|
BAZ2B bromodomain (2064-2168 aa) (GST-tagged), Human recombinant
A protein regulating the transcription of target promoters
Product Overview
Product Name: BAZ2B bromodomain (2064-2168 aa) (GST-tagged), Human recombinant
Alternate Name/Synonyms: Bromodomain Adjacent to Zinc Finger Domain 2B; KIAA1476; WALp4
Gene Symbol: BAZ2B
Accession #: Q9UIF8
Gene ID: 29994
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
Molecular Weight: 40.2 kDa (2064-2168 aa + NT GST Tag)
Purity by SDS-PAGE: ≥80%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BAZ2B is expressed in heart, skeletal, testis, and pancreatic tissues. A rare allele of BAZ2B has been identified to be a predictor of Sudden Cardiac Death.4 The full-length protein contains several DNA-targeting domains, including a methyl-CpG binding domain, a DNA-binding DDT domain, and a tandem PHD-bromodomain. This protein product contains the bromodomain of BAZ2B.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |