Irisin, human recombinant Activates beige fat cells Product Overview Product Name: Irisin, human recombinant Alternate Name/Synonyms: Fibronectin Type III Domain-containing Protein 5, (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved). Gene Symbol: FNDC5 Accession #: Q8NAU1 Gene ID: 252995 Source: E. coli Appearance: Lyophilized powder Physical Form Description: Lyophilized from PBS. Molecular Weight: ~12.0 kDa Purity by SDS-PAGE: ≥95% Purity by HPLC: N/A Endotoxin Level: N/A Biological Activity: N/A Reconstitution Instructions: Reconstitute to 0.1 mg/ml with 100 µl sterile water Storage Temp.: -20°C Shipping: Gel pack Background Information: Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Amino Acid Sequence: N/A Handling: Centrifuge the vial prior to opening USAGE: For Research Use Only! Not For Use in Humans.