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Simvastatin
Description
A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.
Specifications
Cas No. 79902-63-9
Product ID S3449
Product Name Simvastatin
Chemical Name 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
Synonym Synvinolin; MK-733; Denan; Liponorm; Lodales; Simovil; Sinvacor; Sivastin; Zocor; Zocord
Formula Wt. 418.57
Melting Point 135-138 oC
Purity 97%
Solubility (mg/ml) DMSO 540; ethanol 160; methanol 200; water 0.03.
Store Temp Ambient
Ship Temp Ambient
References Inano H. Suzuki K. Onoda M. Wakabayashi K. Carcinogenesis. 18:1723-7 (1997). Kikuchi T. Nagata Y. Abe T. J Neurooncol. 34:233-9 (1997). Lishner M. Bar-Sef A. Elis A. Fabian I. J Investig Med. 49:319-24 (2001). Mol, M.J.et al Lancet 2:936 (198
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