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5-Hydroxytryptophol
Description
5-hydroxytryptophol is an analog of serotonin and melatonin found in the needles of the Pinus sylvestris tree, wine, and beer, and is also the sleep-inducing component of the ‘sleeping sickness’ produced by the Trypanosoma brucei parasite. This compound is often used as a biomarker for recent alcohol consumption is it remains in the body much longer than ethanol. 5-hydroxytryptophol exudes some hypnotic activity, inducing a short-lived sleep state, and marginal antioxidant activity, inhibiting oxidation of LDL in a developmental atherosclerosis model.
Specifications
Cas No. 154-02-9
Product ID H9812
Product Name 5-Hydroxytryptophol
Synonym 2-(5-Hydroxy-3-indolyl)ethyl alcohol
Formula C10H11NO2
Formula Wt. 177.20
Store Temp 4 oC protect from light
Ship Temp Ambient
References Beck O, Helander A. 5-hydroxytryptophol as a marker for recent alcohol intake. Addiction. 2003 Dec;98 Suppl 2:63-72. PMID: 14984243.
Wang HX, Liu F, Ng TB. Examination of pineal indoles and 6-methoxy-2-benzoxazolinone for antioxidant and antimicrobial effects. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Nov;130(3):379-88. PMID: 11701394.
Cornford EM, Bocash WD, Braun LD, et al. Journal of Clinical Investigation 1979;63(6):1241–8. PMID: 447842.
Feldstein A, Chang FH, Kucharski JM. Tryptophol, 5-hydroxytryptophol and 5-methoxytryptophol induced sleep in mice". Life Sciences 1970;9 (6):323–9. PMID: 5444013.
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