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Rhyncholphylline
Description
An alkaloid isolated from Uncaria sinensis. It is one of the active components that protect against glutamate-induced neuronal death in cultured cerebellar granule cells by inhibition of Ca2+ influx. Also found to reduce epileptic seizures. It inhibits apoptosis induced by dopamine in NT2 neurons.
Specifications
Cas No. 76-66-4
Product ID R3197
Product Name Rhyncholphylline
Synonym Rhynchophylline
Formula C22H28N2O4
Formula Wt. 384.47
Purity ≥98.0%
References Shimada Y, Goto H, Itoh T, et al. J Pharm Pharacol. 51:715-22 (1999). Hsieh CL, Ho TY, Su SY, et al. Am J Chin Med. 2:351-60 (2009). Shi JS, Kenneth HG Acta Pharmacol Sin. 23:445-9 (2002).
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