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Paclitaxel (Natural-from Taxus yunnanensis Cheng et L.K.Fu)
Description
A natural diterpenoid originally isolated from the stem bark of Taxus brevifolia. It promotes the assembly of stable microtubules and inhibits the disassembly process of microtubules to tubulin by calcium ions and by low temperature. Taxol was shown to have activity against cancers, such as P388 and L1210 leukemia, B16 melanoma, WM-256 carcinosarcoma, Sarcoma 180, Lewis lung tumor, and several xenografts of human tumors including MX-1 mammary, LX-1 l
Specifications
Cas No. 33069-62-4
Product ID P0092
Product Name Paclitaxel (Natural-from Taxus yunnanensis Cheng et L.K.Fu)
Synonym Taxol; Taxol A; Paxene
Formula Wt. 853.9
Melting Point 213oC-217oC
Purity ≥98%
Solubility Insoluble in water. Soluble in ethanol or DMSO (50mg/ml).
Store Temp -20oC
Ship Temp Ambient
References Wani, M. C., Taylor, H. L., Wall, M. E., Coggon, P., McPhail, A. T. J. Am. Chem. Soc. 93:2325 (1971). Manfredi, J. J., Horwitz, S. B. Pharmacol. Ther. 25:83 (1984). Parness, J., Horwitz, S. B. J. Cell Biol. 91:479 (1981). Schiff, P. B., Fant, J
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