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Doxycycline Monohydrate
Description
Doxycycline is a synthetic teracycline. Inhibits angiogenesis in a quantitative in vitro assay of angiogeneis. Inhibits proliferation of the human leukemia cell line K562. It reduces lung metastases by inhibiting the secretion and acitivity of marrix metalloproteinases (MMPs).
Specifications
Cas No. 17086-28-1
Product ID D5898
Product Name Doxycycline Monohydrate
Chemical Name [4S-(4a,4aa,5a,5aa,6a,12aa)]-4-(Dimethylamino)-1,-4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-penta- hydroxy-6-methyl-1,11-dioxo-2-naphthacenecarbox- amide monohydrate
Synonym Doxycycline; Jenacyclin; Supracyclin; Vibramycin
Formula Wt. 462.45
Melting Point 201oC
Purity ≥97%
Solubility Soluble in ethanol or methanol.
Store Temp Ambient
References Fife RS, Sledge GW Jr, Sissons S, Zerler B. Cancer Lett. 153:75-8 2000. Kasono K. et al. Cancer Gene Ther. 7:151-9 2000. Lokeshwar BL. An. NY. Acad. Sci. 878:271-89 1999.
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