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Human Recombinant Cyclophilin D
An immunophilin family protein catalyzing the isomerization of peptide bonds
Product Overview
Product Name: Human Recombinant Cyclophilin D
Alternate Name/Synonyms: Peptidylprolyl isomerase D, PPID, CYPD, CYP-40
Gene Symbol: PPID
Accession #: Q08752
Gene ID: 5481
Source: E. coli
Appearance: Liquid
Physical Form Description: 1 mg/ml solution in PBS (pH 7.4) containing 10% glycerol.
Molecular Weight: 42.9 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: Specific activity is > 210 nmoles/min/mg
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Gel pack
Background Information: Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. Cyclophilin D is also a mitochondrial matrix protein, which plays a decisive role in mitochondrial permeability transition. It can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |