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Human Recombinant Cyclophilin B
An immunophilin family protein catalyzing the isomerization of peptide bonds
Product Overview
Product Name: Human Recombinant Cyclophilin B
Alternate Name/Synonyms: PPIB, Peptidyl prolyl isomerase B, CYPB; SCYLP; CYP-S1
Gene Symbol: PPIB
Accession #: P23284
Gene ID: 5479
Source: E. coli
Appearance: Liquid
Physical Form Description: 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20 mM NaCl, 0.5 mM DTT, 10% glycerol.
Molecular Weight: 21.2 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method)
Biological Activity: Specific activity is > 220 nmoles/min/mg
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Gel pack
Background Information: Cyclophilin B is a cyclosporine-binding protein. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl cis/trans isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones. It also bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
Amino Acid Sequence: MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEK GFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAG KDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |