HMTase Inhibitor VI, BRD4770

产品编号：	382194-10MG 查看说明书
产品名称：	HMTase Inhibitor VI, BRD4770 .0 订购此产品
供应商：	Merck
规格：	***
目录价：	1,778.00
库存状态：	3周到货
CAS编号：
应用范围：	生化实验
种属来源：
相关信息：
HMTase Inhibitor VI, BRD4770 A cell-permeable analog of the amino-benzimidazolo BIX-01338 (Cat. No. 539212) and the methylester prodrug of BRD9539 that acts as an SAM-competitive inhibitor against PRC2 and G9a (IC50 ≤6.3 µM) histone methyltransferase activities, displaying little effect toward 10 other HMTases, 9 HDACs, and 100 cellular kinases. Selectively reduces H3K9me2 and H3K9me3 (EC50 = 5 µM) histone methylation levels in pancreatic cancer cells (PANC-1) with much less or little effect toward H3K36me3, H3K4me3, H3K27me3, or H3K6me3 levels. Inhibits both anchorage-dependent and -independent PANC-1 proliferation via ATM activation and G2/M cell-cycle arrest, but not apoptosis induction (no caspase3/7 activation; 10 µM, 72 h). 产品信息 Form White powder Primary Target G9a and PRC2 HMTases Molar mass 413.5 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Reversible 是的 Purity ≥98% by HPLC Solubility DMSO 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling
保存条件：	2°C - 8°C
说明书地址：	点击查看详细

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