GSK-3β Inhibitor XXVII 3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl A cell-permeable pyridinylpyrazinecarboxamide compound that acts as a highly potent, reversible, and ATP-competitive inhibitor of GSK-3β (Ki = 4.9 nM) with ~110-fold greater selectivity over Cdk2 (Ki = 540 nM). Shows only a trivial effect on the activities of 26-related kinases at much higher doses. Blocks GSK-3β-mediated phosphorylation of Ser396 in stably transfected 3T3 fibroblasts expressing four-repeat tau protein (IC50 = 76 nM). Readily crosses blood-brain barrier and exhibits desirable bioavailability and aqueous solubility. 产品信息 Form Yellow powder Primary Target GSK-3β Molar mass 634.8 Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Cell permeable 是的 Reversible 是的 Purity ≥99% by HPLC Solubility DMSO Chemical formula C21H23N7O3S• 2.5 HCl•5H2O 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling