PME-1 Inhibitor, AMZ-30 (E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile, NIH Probe ML136 A cell-permeable sulfonyl acrylonitrile compound that acts as a potent and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM and 2.5 µM in human cell lysates and in HEK 293T cells, respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20 µM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells. 产品信息 Form Yellow solid Molar mass 462.6 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility DMSO Chemical formula C19H13FN3O6S2 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling