Neuroprotectant, OBA-09 2-(2-Oxopropanoyloxy)Benzoic Acid A brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties. Following its uptake by the brain tissue, it releases pyruvate and salicylic acid via ester hydrolysis (t1/2 of 43 min in serum). Exerts strong neuroprotective effects in the post-ischemic brain and significantly reduces infarct volume (27% and 65% reduction in 6 and 12 hours following i.v. administration of 10 mg/kg in a rat model). Also, blocks Zn2+-induced neuronal cell death. Its neuroprotective effects are attributed to its ability to prevent NAD- and ATP-depletion in post-ischemic brain and suppression of NF-κB activity by reducing IκB-α degradation. 产品信息 Form White solid Molar mass 208.2 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥99% by HPLC Solubility DMSO Chemical formula C10H8O5 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling