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MT1-MMP Inhibitor, NSC405020
3,4-Dichloro-N-(pentan-2-yl)benzamide, 3,4-Dichloro-N-(1-methylbutyl)benzamide
A cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-β3/MT tumor growth in xenografted mice (0.5 mg/kg, intratumoral).
产品信息
Form Off-white solid
Molar mass 260.2
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C12H15Cl2NO
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |