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CXCR4 Antagonist III
N2-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N4-(piperidin-4-yl) quinazoline-2,4-diamine, 2HCl, Fusin Antagonist III
A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC50 = 36.2 nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC50 >10 µM). Shown to inhibit CXCL12-induced Ca2+-mobilization and cell migration in hCXCR4-HEK293 cells (IC50 = 100.1 and 41 nM, respectively), and rapidly mobilize CXCR4+, CD34+ and CD133+ stem cells from bone marrow in C57BL/6 male mice (6 mg/kg, s.c).
产品信息
Form White solid
Primary Target CXCR4
Molar mass 574.6
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥98% by HPLC
Solubility H2O
Chemical formula C30H43N7•2HCl
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |