Herg Activator, NS1643 A diphenolurea compound that selectively activates human ether-a-go-go-related gene (hERG) K+-channel (EC50 = 10.5 µM). Shown to significantly increase both steady-state and peak tail currents of hERG channels, but exhibits only a trivial effect on Kv4.3 and Kv1.5 channels. Causes a significant reduction in action potential duration (APD90 ) in patch clamp assays in Xenopus oocytes, HEK293 cells, and guinea pig cardiamyocyes that can be reversed by the addition of E-4031 (Cat. No. 324470), a specific blocker of hERG channels. Also shown to activate IKr channel in cardiomyocytes and increase post-repolarization refractory time thereby alleviating hyper-excitability and producing antiarrhythmic effects. It can also restore IKr reduced by down-regulation of IKr expression. 产品信息 Form Off-white powder Molar mass 380.2 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility DMSO Chemical formula C15H10F6N2O3 CAS number 448895-37-2 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling