TRPM4 inhibitor, 9-Phenanthrol Phenanthren-9-ol, 9-Hydroxyphenanthrene A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents. 产品信息 Form Brown solid Molar mass 194.2 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥95% by HPLC Solubility DMSO Chemical formula C14H10O CAS number 484-17-3 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Irritant