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Syk Inhibitor V
(S)-2-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-N-(1-hydroxypropan-2-yl)-4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor
A cell-permeable 4-thiazolyl-2-phenylaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of spleen tyrosine kinase (Syk) (Ki = 9nM). Exhibits excellent selectivity over Cdk2 (Ki >= 3.33 µM); ROCK (Ki = 2.3 µM), Src (Ki >= 3.33 µM) and ZAP 70 (Ki = 240 nM). Shown to inhibit mast cell degranulation (IC50 = 70 nM) that is commonly observed in asthma and other allergic diseases.
产品信息
Form Yellow solid
Molar mass 397.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥99% by HPLC
Solubility DMSO
Chemical formula C20H23N5O2S
商店和运输信息
Storage -20°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review |