SOD1 Inhibitor, LCS-1

产品编号：	567417-10MG 查看说明书
产品名称：	SOD1 Inhibitor, LCS-1 .0 订购此产品
供应商：	Merck
规格：	***
目录价：	1451
库存状态：	3周到货
CAS编号：	41931-13-9
应用范围：	生化实验
种属来源：
相关信息：
SOD1 Inhibitor, LCS-1 lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes. 产品信息 Form White solid Molar mass 255.1 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥99% by HPLC Solubility DMSO Chemical formula C11H8Cl2N2O CAS number 41931-13-9 商店和运输信息 Storage -20°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling
保存条件：	-20°C
说明书地址：	点击查看详细

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