Polo-like Kinase Inhibitor V, Poloxin

Polo-like Kinase Inhibitor V, Poloxin
Polo-like Kinase Inhibitor V, 2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone
A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50) = 4.8 µM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 µM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg.
产品信息
Form  Yellow solid
Molar mass  297.35
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C18H19NO3
CAS number  321688-88-4
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling