c-Myc Inhibitor III, Mycro2

c-Myc Inhibitor III, Mycro2
5-(Thiophen-2-yl)-N-(thiophen-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
A cell-permeable pyrazolopyrimidine-carboxamide that selectively inhibits c-Myc-Max dimer DNA binding activity (IC50 = 23 µM) by preventing c-Myc-Max heterodimer formation, while affecting Max, Jun, C/EBPα homodimers, or Jun-Fos heterodimer DNA binding only at much higher concentrations (IC50 = ≥54 µM). Shown to selectively inhibit c-Myc-Max-dependent transcription (by 77% against E-Box promoter-driven reporter transcription at 10 µM), cancer proliferation, and anchorage-independent colony formation (Effective conc. 10-20 µM).
产品信息
Form  Yellow solid
Primary Target  α-helical dimerization motifs of c-Myc/Max factors
Primary Target IC50  IC50 = 23 and 54 µM for c-Myc/Max and Max/Max dimerization
Secondary target  α-helical dimerization motifs of Max/Max factors
Molar mass  408.4
Protect from Light  是的
Packaged under inert gas  是的
Cell permeable  是的
Reversible  是的
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C17H11F3N4OS2
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling