MNK1/2 Inhibitor II, ETP-45835

MNK1/2 Inhibitor II, ETP-45835
ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl
A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50 = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (≤15% inhibition at 5 µM). Reported to exhibit good aqueous solubility (> 100 µM at pH 7.4) and inhibit the proliferation (IC50 = 17 µM) and cellular eIF4E Ser209 phosphorylation (IC50 = 4.7 µM) of MV4:11 cells.
产品信息
Form  White solid
Molar mass  301.2
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥98% by HPLC
Solubility  H2O
Chemical formula  C13H16N4•2HCl
商店和运输信息
Storage  -20°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling